Diabetes & Pharmacogenomics (PGx)
Pharmacogenomics (PGx) is the study of how a person's unique genetic makeup (genome) influences his or her response to medications, especially for diabetes patients on two (2) or more medications.
More than 85% of patients have significant genetic variations in the most important cytochromes  – CYP2D6, CYP2C9, CYP2C19, CYP3A4 and CYP3A5. For example, CYP3A4 and CYP3A5 affect the metabolism of one-half of the drugs in clinical use, and this variance is profoundly affected based on patient ethnicity. Additionally, Factor II Leiden (Factor 2 Leiden) and Factor V Leiden protein variations can increase the risk of dangerous cardiovascular events.
One variation example is CYP2D6. CYP2D6 acts on 25% of all prescription drugs. Approximately 7% of the population has a slow acting form of this enzyme and 7% a super-fast acting form. 35% are carriers of a non-functional CYP2D6 allele, which especially elevates the risk of ADEs when these individuals are taking multiple drugs.
Prescription Medication Use by Older Adults
More than 29 million people in the United States have diabetes. As such, millions of Americans currently take diabetes medications. Over half of all medications for diabetes, including the majority of oral hypoglycemic medications, are metabolized by two enzymes in the liver called CYP2C9 and CYP2C19.
Your genes are the main factor in determining the level of these enzymes primarily found in your liver — if you have too much of the enzyme, you process the medication too quickly, too little of the enzyme and the medication builds up in your bloodstream potentially causing adverse reactions or side effects.
34% of Older Adults in the US are Prescribed Potentially Inappropriate Drugs.
Genetics and Medications
When seeing a medical provider for a certain health condition or concern, patients are often prescribed a medication — and many times, multiple medications. Patients fill their prescriptions, take the medications for a period of time, and check-in with their provider to discuss how they're feeling, what side effects they're experiencing, and to explore potential alternatives.
This takes time — a valuable time when patients may still be experiencing the same effects. And, each new medication costs money.
This method is known as trial-and-error. Patients and their providers work together over time to find a medication regimen that really works for them. But, given the advancement in precision medicine, PGx testing has become available to patients to help inform them how medications and their genes may be interacting. Pharmacogenetic testing complements current efforts to optimize personalized care in diabetes patients— all while being more cost-effective and reducing trial-and-error efforts.
Seniors 65-Years Account for 34% of All Prescription Medication Use.
Pharmacogenetic (PGx) testing bridges the gap in understanding how the role of how genetics can help with patient care and offers a simple non-invasive DNA test (buccal swab) that provides a report of the results to providers that can be discussed with patients.
A Simple Value-Based Resource
- Allergic Reactions
- Cardiovascular Disease
- Chronic Conditions
- Mental Health
Get Tested If
- Two (2) or more medications are being taken
- Personalized Medications
- Point-of-Care Testing
- Improve Your Quality HEDIS/STAR Ratings
- Providers Real-Time Results
- Maximizes Patient and Provider Engagement
- Improves Patient Satisfaction