Diabetic Neuropathy Device™
Assess Small & Large Nerves
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#1 NERVE Supplement Science-Backed by Aaron Vinik MD PhD
Diabetic Peripheral Neuropathy (DPN)
The Diabetic Neuropathy Device™ (DND) is the only FDA-registered neuropathy tool that measures both small fiber (temperature) and large fiber (vibration) nerve function in under 3 minutes—providing objective, reproducible results far beyond tuning forks or monofilaments. This distinction matters: most diabetes-related amputations stem from large fiber neuropathy that often goes undetected with conventional testing. Supported by Medicare-eligible CPT codes, the DND enables early, accurate detection so providers can intervene sooner, prevent complications, and preserve mobility, while keeping care and revenue in-house.
Unlike monofilament subjective pinprick tests or tuning forks, the DND delivers quantifiable data in 3-minutes or less—enabling early detection, documented medical necessity, and multi-visit therapy planning.
Temperature (Small Fiber)
Temperature (Small Fiber)
The Device (DND) Replaces Tuning Forks and Monofilaments...
The Device (DND) Replaces Tuning Forks and Monofilaments...
Kazu Suzuki DPM, Medical Director of the Tower Wound Care Center at the Cedars-Sinai Medical Towers in Los Angeles, CA; Managing Neuropathy And Pain In Wound Care Patients, Podiatry Today; September 2015; 26-27.
Site-Specific Predictive Biomarkers
Site-Specific Predictive Biomarkers
Vibration (Large Fiber)
Vibration (Large Fiber)
"Every medical practice should test patients with the DND before referring them to a specialist because it can help identify potential underlying conditions that may require further investigation or treatments." -J. Gonzalez MD, Neurologist
Comprehensive Foot Exams (Painful/Painless)
Comprehensive Foot Exams (Painful/Painless)
People with diabetes live longer, healthier lives with fewer complications thanks to technological advances that enable earlier identification and intervention. These innovations have revolutionized diabetes management, improving patient outcomes and quality of life. It is now essential, if not an obligation, for medical providers to adopt modern, objective diagnostic tools rather than relying on outdated methods such as tuning forks (invented in 1711) and monofilaments (invented in 1938). Diabetic neuropathy, a common and serious complication of diabetes, often leads to significant morbidity and mortality. The epidemiology and progression of this condition remain unclear, partly due to limitations in traditional diagnostic tools. Primary care providers are pivotal in the early detection of foot-related issues, as they are often the first point of contact for patients experiencing discomfort. By utilizing advanced, objective methods to diagnose neuropathy, providers can ensure timely interventions and reduce the risk of life-altering complications.
People with diabetes live longer, healthier lives with fewer complications thanks to technological advances that enable earlier identification and intervention. These innovations have revolutionized diabetes management, improving patient outcomes and quality of life. It is now essential, if not an obligation, for medical providers to adopt modern, objective diagnostic tools rather than relying on outdated methods such as tuning forks (invented in 1711) and monofilaments (invented in 1938). Diabetic neuropathy, a common and serious complication of diabetes, often leads to significant morbidity and mortality. The epidemiology and progression of this condition remain unclear, partly due to limitations in traditional diagnostic tools. Primary care providers are pivotal in the early detection of foot-related issues, as they are often the first point of contact for patients experiencing discomfort. By utilizing advanced, objective methods to diagnose neuropathy, providers can ensure timely interventions and reduce the risk of life-altering complications.
Get Reimbursed for Foot Exams
Monofilament testing, although affordable and widely used, is not without limitations. The perception that inexpensive tools like monofilaments are sufficient for diagnosing neuropathy can lead to delayed interventions and an increased risk of complications. A study published in the Journal of Diabetes Science and Technology highlighted that monofilaments have a sensitivity of only 64% for detecting diabetic peripheral neuropathy, raising concerns about their reliability. This underscores the need for more accurate and objective diagnostic methods to ensure early detection and better patient outcomes. Relying on subjective and outdated tools such as monofilaments or tuning forks risks false negatives that delay critical care and false positives that lead to unnecessary interventions. Medical providers must consider modern alternatives that improve diagnostic accuracy and qualify for reimbursements, ensuring better care and financial viability for clinics.
Diabetic and Non-Diabetic
The Diabetic Neuropathy Device™ (DND), introduced in 2014, represents a significant advancement in detecting and measuring neuropathy. Clinical studies demonstrate that the DND provides more precise and reliable results than traditional tools like monofilaments and tuning forks, which are prone to false positives and negatives.
With the DND, medical providers can standardize diabetic foot exams across the United States, ensuring consistent and effective patient care. This groundbreaking tool enables accurate diagnosis and monitoring of diabetic neuropathy, leading to timely treatments and improved outcomes. Recognized as the most significant innovation in diabetic neuropathy detection in over 80 years, the DND is a clinical necessity and eligible for reimbursement from Medicare, Medicaid, and commercial insurers.
Investing in the DND is an investment in better patient outcomes, reduced complications, and a modernized approach to neuropathy care. By adopting this innovative device, providers can elevate their standard of care and ensure that patients receive the best possible management for diabetic and non-diabetic neuropathy.
Diabetic Neuropathy Accounts for More Hospitalizations Than All Other Diabetic Complications Combined...
Aaron Vinik, MD, Ph.D., Endocrinologist, Diabetic Neuropathies, February 5, 2018
"The DND has improved the patient understanding of their disease, which is very helpful." - W. Beaton DPM
In the U.S., an estimated that up to 85% of lower extremity amputations among persons with diabetes can be prevented with improved foot care programs.
In the U.S., an estimated that up to 85% of lower extremity amputations among persons with diabetes can be prevented with improved foot care programs.
Bild DE, et al. Lower Extremity Amputations in People with Diabetes: Epidemiology and Prevention. Diabetes Care 1989; 12:24-31; CDC MMWR November 01, 1991 / 40(43);737-7
What Makes it Different:
What Makes it Different:
Dual-Fiber Detection
Detects both small (unmyelinated) and large (myelinated) nerve damage—critical for diabetic and prediabetic patients
Fully Objective & Non-Invasive
No guesswork, no pain—just reproducible results providers can trust
Medicare-Eligible
Valid CPT codes supported by strong clinical documentation
Testing in 3 Minutes or Less
Fits into your existing workflow without disrupting patient volume
Supports Amputation Prevention Protocols
Ideal for patients with diabetes, PAD, or CKD—before symptoms become irreversible
"We regularly use the Diabetic Neuropathy Device™ (DND) to monitor our diabetic patients who are at risk for developing diabetic neuropathy, as well as patients who are already diagnosed with diabetic neuropathy." -C. Soller NP, Endocrinology
Modern Technology
The Diabetic Neuropathy Device™ (DND) aligns with the latest screening and diagnostic recommendations from the American Diabetes Association (ADA). As the only tool capable of screening for distal symmetric polyneuropathy (DSPN) by assessing both temperature sensitivity (small fiber function) and vibration perception (large fiber function), the DND sets a new standard in neuropathy diagnostics, as emphasized in the ADA’s Diabetic Neuropathy: A Position Statement by the American Diabetes Association.
Tailored neuropathy treatments are essential to address each patient’s unique clinical presentation and underlying pathology while avoiding the risks associated with opioid use. For example, treating painful neuropathy with pain-relieving medications alone may mask loss of protective sensation (LOPS) in the feet, leaving patients vulnerable to foot ulcers and amputation. Early and accurate identification of neuropathy allows providers to intervene at the earliest stages of the condition, effectively reducing risk factors and improving outcomes.
By leveraging advanced tools like the DND, medical providers can enhance their ability to diagnose, monitor, and manage diabetic neuropathy, ultimately protecting patients from severe complications and improving their quality of life.
Don't Change Your Workflow, Just Your Tools!
Two Major Modalities in One Simple-to-Use Handheld Device
Two Major Modalities in One Simple-to-Use Handheld Device
Boris Golosarsky, MD MACP FACPI, Podiatry Management, Profiles in Excellence, January 2015
The DND objectively measures both small and large fiber neuropathy—enabling earlier detection, full nerve assessment, and more comprehensive diagnostics in one device.
"We use the DND because it gives us both the small and large fiber results that we feel are important for every diabetic patient." -R. Cardenas MD, Family Practice
Morbidity and Mortalities
Neuropathy is a serious condition that, if not accurately diagnosed and treated promptly, can lead to devastating outcomes, such as amputations of the toes, feet, or legs. The failure to adopt advanced diagnostic tools and procedures has resulted in medical institutions and physicians being held liable for malpractice. A landmark case, Washington v. Washington Hospital (1990)., set legal precedent in the U.S. regarding this issue.
To mitigate these risks, clinicians must stay informed about emerging best practices that are supported by clinical evidence. By adopting advanced technologies and emphasizing prevention, healthcare providers can improve patient outcomes while reducing the risk of complications. Proactive strategies, such as reallocating resources toward early detection and intervention, enable the administration of appropriate therapies. This approach can ultimately decrease the need for frequent inpatient and outpatient visits, significantly enhancing patients' quality of life.
"...by the time a patient fails the monofilament test, he or she may have a profoundly severe neuropathy, and it may be too late to intervene."
"...by the time a patient fails the monofilament test, he or she may have a profoundly severe neuropathy, and it may be too late to intervene."
Kazu Suzuki DPM, Medical Director of the Tower Wound Care Center at the Cedars-Sinai Medical Towers in Los Angeles, CA; Managing Neuropathy And Pain In Wound Care Patients, Podiatry Today; September 2015; 26-27.
Diabetic Neuropathy (DN) is Grossly Underdiagnosed and Undertreated.
Diabetic Neuropathy (DN) is Grossly Underdiagnosed and Undertreated.
Aaron Vinik, MD, PhD, FCP, MACP, FACE, et al, Endocrinologist, Diabetic Neuropathies, February 5, 2018
Identifying the following nerve fibers may increase earlier awareness and interventions:
Aα fibers are large myelinated fibers in charge of motor functions and muscle control.
Aβ fibers are large myelinated fibers with sensory functions such as perception to touch, vibration, and position.
Aδ fibers are small myelinated fibers in charge of pain stimuli and cold perception.
C fibers can be myelinated or unmyelinated and have sensory (warm perception and pain) and autonomic functions (blood pressure and heart rate regulation, sweating, etc.).
"One of the great advantages of using the DND on our diabetic patients who have started to develop diabetic neuropathy, is that showing them their results, often makes the consequences of not taking care of themselves more realistic." -Dr. Steve, Neuropathy Centers
Importance of Specificity
Diabetics that have lower-extremity amputations have lifespans that range between 40% mortality in 1-year, 65% mortality in 3-years, and 80% mortality in 5-years. Diabetic Neuropathy is a serious diabetes complication affecting as many as 50% of people who suffer from pain, and another 50% may be asymptomatic - who are at the highest risk of falls, ulcerations, and amputations. Nerve damage and poor circulation are the most common causes of diabetic foot problems. One of the most underdiagnosed and untreated parts of a comprehensive foot exam is checking the loss of protective sensation (LOPS) in the feet. The diabetic large nerve fiber dysfunction, as measured by vibration, predicts foot ulcerations, amputations, and mortality.
(Painless) Diabetic large nerve fiber dysfunction as measured by vibration Predicts foot ulceration, amputation and mortality.
(Painless) Diabetic large nerve fiber dysfunction as measured by vibration Predicts foot ulceration, amputation and mortality.
https://care.diabetesjournals.org/content/32/10/1896
The purpose of a comprehensive diabetic foot exam is to gather as much clinical data about the condition of a person's normal or abnormal condition in the feet of both large and small nerve fibers. A diabetic foot exam also checks people with diabetes for infection, injury, and bone abnormalities. However, over 99% of all medical providers use outdated and subjective tools (tuning fork, invented in 1711 or monofilaments, invented in 1938) to identify a progressive disease. Distal Symmetric Polyneuropathy (DSPN), a glove and stocking distribution, is the most common form of Diabetic Neuropathy (DN) and is recognized as the most troublesome complication of diabetes mellitus leading to the greatest morbidity and mortality, which accounts for the most amount of hospitalizations than all other diabetic complications combined and is responsible for up to 75% of non-traumatic amputations.
(Painful) Diabetic small fiber neuropathy can only be verified with thermal thresholds or skin biopsies.
(Painful) Diabetic small fiber neuropathy can only be verified with thermal thresholds or skin biopsies.
Aaron Vinik, MD, Ph.D., Endocrinologist, Diabetic Neuropathies, February 5, 2018
The proper diagnosis of diabetic neuropathy should require tools to identify and measure the disorder quantitatively for the different abnormalities that occur to specific nerve fibers. Combining at least two different examinations (large and small fiber) will increase the sensitivity and specificity of detecting DPN. Currently, many medical providers are unaware of reimbursable tools that address both large fiber and small fiber neuropathy, both of which manifest in patients with diabetes. The Diabetic Neuropathy Device™ is the first FDA Cleared multi-objective tool with 15 measurements that identify both large and small nerve fibers in the upper and lower extremities.
"It is imperative that we use our ability to measure quantitatively the different types of defects that occur in the disorder (DN), so the appropriate therapies can be targeted to specific nerve fiber types."
"It is imperative that we use our ability to measure quantitatively the different types of defects that occur in the disorder (DN), so the appropriate therapies can be targeted to specific nerve fiber types."
Aaron Vinik, MD, PhD, FCP, MACP, FACE, et al, Endocrinologist, Diabetic Neuropathies, February 5, 2018
Mechanism of Action
Mechanism of Action
The Diabetic Neuropathy Device™ (DND) is a modern, non-invasive tool that identifies early signs of peripheral neuropathy by testing both sensory and autonomic nerve function. The DND operates by assessing the autonomic nervous system’s sudomotor function using a method called the Sympathetic Skin Response (SSR). SSR evaluates the small C-fibers in the skin responsible for sweat responses that are independent of body temperature regulation. These specific fibers are often the first to be affected in small fiber peripheral neuropathy, a condition that impairs the nerves controlling pain and temperature sensations—especially in diabetic patients.
Traditionally, these evaluations have relied on monofilaments and tuning forks. However, the DND advances this process by delivering precise temperature and vibration stimuli, helping to measure nerve integrity quickly and reproducibly. This methodology is supported by clinical guidelines from multiple professional organizations, including the American Diabetes Association (ADA). By using SSR, the DND captures subtle changes in skin potential linked to nerve activity. This test has proven useful not only in diagnosing diabetic polyneuropathy but also in identifying autonomic involvement in conditions like:
Central nervous system disorders (e.g., multiple sclerosis, Parkinson’s)
Peripheral nerve lesions
Reflex sympathetic dystrophy
Erectile dysfunction and other autonomic disorders
With the DND, providers can objectively assess both small and large nerve fiber function—right in the office—in about 3 minutes.
Quantitative Sensory Testing (QST) and Sympathetic Skin Response tests (SSR) are distinct diagnostic procedures employed to assess the nervous system: QST focuses on evaluating sensory function by measuring the perception of stimuli, including touch, temperature, and pressure, commonly used in neurology to assess peripheral neuropathy; whereas SSR assesses the sympathetic nervous system's activity by measuring changes in skin conductance in response to stress or stimuli, often applied in neurology to evaluate autonomic nervous system function, with key differences lying in their respective focuses, stimuli application methods, and measurements. Multiple studies have proven the value of Quantitative Sensory Testing (QST) measures in the detection of subclinical neuropathy (small fiber neuropathy), the assessment of the progression of neuropathy, and the prediction of the risk of foot ulceration (117,129,130). These standardized measures of vibration and thermal thresholds also play an important role as primary efficacy endpoints in multicenter clinical trials.
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